Structural Basis for Molecular Interactions in DNA Damage Tolerance
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چکیده
منابع مشابه
Structural basis for the molecular interactions in DNA damage tolerances
DNA damage tolerance (DDT) is a cell function to avoid replication arrest by DNA damage during DNA replication. DDT includes two pathways, translesion DNA synthesis (TLS) and template-switched DNA synthesis (TS). DDT is regulated by ubiquitination of proliferating cell nuclear antigen that binds to double-stranded DNA and functions as scaffold protein for DNA metabolism. TLS is transient DNA sy...
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*Correspondence: Takashi Yagi, Laboratory of Molecular and Cellular Genetics, Department of Biology, Graduate School of Science and Radiation Research Center, Osaka Prefecture University, 1-2, Gakuen-cho, Naka-ku, Sakai, Osaka 599-8570, Japan e-mail: [email protected] Formaldehyde is commonly used in the chemical industry and is present in the environment, such as vehicle emissions, ...
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DNA damage may compromise genome integrity and lead to cell death. Cells have evolved a variety of processes to respond to DNA damage including damage repair and tolerance mechanisms, as well as damage checkpoints. The DNA damage tolerance (DDT) pathway promotes the bypass of single-stranded DNA lesions encountered by DNA polymerases during DNA replication. This prevents the stalling of DNA rep...
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ژورنال
عنوان ژورنال: Seibutsu Butsuri
سال: 2017
ISSN: 0582-4052,1347-4219
DOI: 10.2142/biophys.57.015